Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 13/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23882929 | 0.88 | MAOB (0.63) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| SCHEMBL30251066 | 0.88 | MAOB (0.63) | MAOBMAOAGRM5NPC1ALDH1A1 | |
| SCHEMBL23906278 | 0.77 | BRD4 (0.54) | BRD4CREBBPMAOBMAOAGRM5 | |
| SCHEMBL23905149 | 0.77 | MAOB (0.77) | BRD4CREBBPMAOBMAOAGRM5 | |
| SCHEMBL31525604 | 0.76 | CYP19A1 (0.48) | MAOBALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL1500280 | 0.76 | CYP19A1 (0.48) | MAOBALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL32675586 | 0.75 | MAOB (0.50) | BRD4CREBBPMAOBMAOAGRM5 | |
| SCHEMBL23882660 | 0.75 | MAOB (0.50) | BRD4CREBBPMAOBMAOAGRM5 | |
| SCHEMBL23905817 | 0.74 | BRD4 (0.67) | BRD4CREBBPMAOBMAOAGRM5 | |
| SCHEMBL23905914 | 0.73 | MAOB (0.47) | BRD4CREBBPMAOBMAOAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021198283-A1 | INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-07 | — | — | WO | disclosed |