Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6022738 | 0.92 | HDAC11 (0.53) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL6022743 | 0.92 | HDAC11 (0.53) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL2389424 | 0.91 | HDAC11 (0.42) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL12257929 | 0.88 | PTPN11 (0.45) | HDAC11PTPN11HDAC2EPHX2FDPS | |
| SCHEMBL2495388 | 0.88 | PTPN11 (0.50) | HDAC11PTPN11HDAC2EPHX2FDPS | |
| SCHEMBL2390064 | 0.87 | HDAC11 (0.48) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL2390768 | 0.86 | MTNR1A (0.41) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL2390721 | 0.85 | HDAC11 (0.49) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL2392575 | 0.85 | PTPN11 (0.55) | HDAC11PTPN11LMNAKDM4EALDH1A1 | |
| SCHEMBL2392187 | 0.84 | HDAC11 (0.50) | HDAC11LMNAKDM4EALDH1A1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |