SCHEMBL23908723

SCHEMBL23908723

CC(C)(C)c1cc(-n2nc3ccc(Cl)cc3n2)c(O)c(C(C)(C)C)c1.O=[Ti]=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
ALOX5 P09917 4/20 0.33
PTGS2 P35354 4/20 0.33
HSP90AA1 P07900 1/20 0.33
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
ATM Q13315 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
ACLY P53396 1/20 0.31
EPHX2 P34913 1/20 0.31
RXFP1 Q9HBX9 1/20 0.30
NR5A2 O00482 1/20 0.30
NR5A1 Q13285 1/20 0.30
HSD17B2 P37059 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29349567 0.95 NPC1 (0.41) NPC1RAB9AALOX5PTGS2HSP90AA1
SCHEMBL29241 0.95 NPC1 (0.41) NPC1RAB9AALOX5PTGS2HSP90AA1
Bumetrizole SCHEMBL5194149 0.89 NPC1 (0.48) NPC1RAB9AHSP90AA1POLBKDM4E
Pyrrole SCHEMBL28116614 0.88 NPC1 (0.39) NPC1RAB9AALOX5PTGS2HSP90AA1
Toluene SCHEMBL29114789 0.87 NPC1 (0.46) NPC1RAB9AALOX5PTGS2POLB
Bumetrizole SCHEMBL8250511 0.86 NPC1 (0.54) NPC1RAB9AALOX5PTGS2HSP90AA1
SCHEMBL11668139 0.86 NPC1 (0.43) NPC1RAB9AALOX5PTGS2HSP90AA1
SCHEMBL6855338 0.86 NPC1 (0.38) NPC1RAB9APOLBKDM4EMAPT
SCHEMBL22372500 0.85 NPC1 (0.44) NPC1RAB9AALOX5PTGS2HSP90AA1
SCHEMBL31419499 0.85 NPC1 (0.43) NPC1RAB9APOLBKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210317297-A1 METHODS AND COMPOSITION OF A DENTAL MODEL FOR THE MANUFACTURE OF ORTHODONTIC APPLIANCES WITHOUT THE USE OF SEPARATOR STRUCTO PTE LTD (SG) 2021-10-14 US disclosed