Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.37 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390735 | 0.95 | HDAC11 (0.40) | HDAC11PTPN11NR0B2PTGER1PTGER4 | |
| SCHEMBL6022621 | 0.93 | HDAC11 (0.47) | HDAC11PTPN11NR0B2PTGER1PTGER4 | |
| SCHEMBL6022615 | 0.93 | HDAC11 (0.47) | HDAC11PTPN11NR0B2PTGER1PTGER4 | |
| SCHEMBL6022897 | 0.86 | HDAC11 (0.47) | HDAC11PTPN11NR0B2PTGER1PTGER4 | |
| SCHEMBL6022901 | 0.86 | HDAC11 (0.47) | HDAC11PTPN11NR0B2PTGER1PTGER4 | |
| SCHEMBL2391779 | 0.86 | HDAC11 (0.45) | HDAC11PTPN11NR0B2S1PR1HDAC2 | |
| SCHEMBL2390957 | 0.86 | HDAC11 (0.45) | HDAC11PTPN11NR0B2S1PR1HDAC2 | |
| SCHEMBL2391835 | 0.86 | PTPN11 (0.48) | HDAC11PTPN11NR0B2HDAC2KDM4E | |
| SCHEMBL2390953 | 0.85 | PSEN1 (0.37) | HDAC11PTPN11NR0B2PTGER1S1PR1 | |
| SCHEMBL2392575 | 0.84 | PTPN11 (0.55) | HDAC11PTPN11NR0B2HDAC2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |