Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | RARG | P13631 | 1/20 | 0.38 |
| ▸ | GOT1 | P17174 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390948 | 0.95 | HDAC11 (0.40) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL6022897 | 0.92 | HDAC11 (0.47) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL6022901 | 0.92 | HDAC11 (0.47) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL6022621 | 0.88 | HDAC11 (0.47) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL6022615 | 0.88 | HDAC11 (0.47) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL2387851 | 0.86 | HDAC11 (0.48) | HDAC11S1PR1HDAC2HDAC8HDAC1 | |
| SCHEMBL2390957 | 0.85 | HDAC11 (0.45) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL2391779 | 0.85 | HDAC11 (0.45) | HDAC11S1PR1HDAC2PTPN11HDAC8 | |
| SCHEMBL2393698 | 0.85 | PTPN11 (0.50) | HDAC11HDAC2PTPN11HDAC8NR0B2 | |
| SCHEMBL2393218 | 0.85 | S1PR1 (0.41) | HDAC11S1PR1HDAC2PTPN11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |