SCHEMBL23910957

SCHEMBL23910957

CNC(=O)c1cc2c(-c3cc(Cl)cc4c3OC(C(=O)N3CCN(C(=O)OC(C)(C)C)CC3)C4)ccnc2[nH]1

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
USP7 Q93009 12/20 0.56
NUDT1 P36639 2/20 0.43
CCNK O75909 3/20 0.43
CDK12 Q9NYV4 3/20 0.43
CCNT1 O60563 2/20 0.39
CDK9 P50750 2/20 0.39
CCNC P24863 1/20 0.39
CDK8 P49336 1/20 0.39
HASPIN Q8TF76 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23911222 0.88 USP7 (0.71) USP7NUDT1CCNKCDK12CCNT1
SCHEMBL23921917 0.88 USP7 (0.71) USP7NUDT1CCNKCDK12CCNT1
SCHEMBL23921918 0.88 USP7 (0.71) USP7NUDT1CCNKCDK12CCNT1
SCHEMBL23911387 0.87 USP7 (0.56) USP7CCNKCDK12CCNT1CDK9
SCHEMBL23911239 0.87 USP7 (0.56) USP7CCNKCDK12CCNT1CDK9
SCHEMBL23910700 0.86 USP7 (0.55) USP7CCNKCDK12CCNT1CDK9
SCHEMBL23910772 0.85 USP7 (0.53) USP7CCNKCDK12CCNT1CDK9
SCHEMBL23911640 0.85 USP7 (0.76) USP7CCNKCDK12
SCHEMBL23911635 0.85 USP7 (0.54) USP7CCNKCDK12CCNT1CDK9
SCHEMBL23910909 0.84 USP7 (0.52) USP7CCNKCDK12CCNT1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210317134-A1 UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF RAPT THERAPEUTICS INC (US) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210317134-A1 UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF USP7, SENP7, USP8 USP7 1/4885NUDT1 2868/4885CCNK 2280/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.