Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | ROS1 | P08922 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.45 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179231 | 0.86 | AURKA (0.65) | AURKAJAK2SYKNTRK1ROS1 | |
| SCHEMBL23911848 | 0.82 | AURKA (0.40) | AURKAJAK2SYKNTRK1ROS1 | |
| SCHEMBL23911847 | 0.80 | AURKA (0.66) | AURKAJAK2SYKNTRK1ROS1 | |
| SCHEMBL11823556 | 0.73 | MAPT (0.71) | ESR1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL11823548 | 0.73 | MAPT (0.71) | ESR1MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL2482275 | 0.70 | AURKA (0.79) | AURKAJAK2SYKNTRK1ROS1 | |
| SCHEMBL23911850 | 0.70 | AURKA (0.81) | AURKAJAK2SYKNTRK1ROS1 | |
| SCHEMBL22579262 | 0.69 | MAPT (0.64) | MAPTMEN1ALDH1A1KMT2ANPC1 | |
| SCHEMBL18455119 | 0.68 | SYK (0.58) | JAK2SYKNTRK1ROS1CSNK2A2 | |
| SCHEMBL21471537 | 0.68 | AURKA (0.73) | AURKAJAK2SYKNTRK1ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | SYK, HDAC1, HDAC2 | AURKA 585/4885ESR1 2811/4885JAK2 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.