Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.38 |
| ▸ | CD63 | P08962 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179230 | 0.89 | AURKA (0.53) | AURKAJAK2SYKCD63BTK | |
| SCHEMBL23911846 | 0.82 | AURKA (0.49) | AURKAMAPTKDM4ELMNAJAK2 | |
| SCHEMBL22641730 | 0.81 | MAPT (0.48) | MAPTKDM4ELMNAHDAC3HDAC1 | |
| SCHEMBL22641675 | 0.76 | MAPT (0.47) | MAPTKDM4ELMNAHDAC3HDAC1 | |
| SCHEMBL22641632 | 0.74 | HDAC3 (0.50) | MAPTKDM4ELMNAHDAC3HDAC1 | |
| SCHEMBL23911847 | 0.74 | AURKA (0.66) | AURKAJAK2SYKCD63BTK | |
| SCHEMBL22579255 | 0.73 | MAPT (0.42) | MAPTKDM4ELMNAHDAC1MEN1 | |
| SCHEMBL23911844 | 0.73 | AURKA (0.58) | AURKAJAK2SYKCD63BTK | |
| SCHEMBL22579296 | 0.71 | MAOB (0.43) | MAPTKDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8318678 | 0.70 | HDAC1 (0.44) | MAPTKDM4ELMNAHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | HANGZHOU INNOGATE PHARMA CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11142535-B2 | Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor | SYK, HDAC1, HDAC2 | AURKA 585/4885MAPT 2895/4885KDM4E 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.