Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 12/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18918869 | 0.92 | ULK1 (0.52) | ULK1BTKRETFLT3ULK2 | |
| SCHEMBL23912139 | 0.84 | ULK1 (0.53) | ULK1BRD4 | |
| SCHEMBL18918783 | 0.83 | ULK1 (0.44) | ULK1BTKCCNT1CDK9RET | |
| SCHEMBL18918791 | 0.79 | ULK1 (0.53) | ULK1RETFLT3ULK2AURKB | |
| SCHEMBL18918687 | 0.79 | ULK1 (0.51) | ULK1RETFLT3ULK2AURKB | |
| SCHEMBL18932445 | 0.79 | ULK1 (0.53) | ULK1RETFLT3ULK2AURKB | |
| SCHEMBL18944135 | 0.79 | ULK1 (0.55) | ULK1BTKRETFLT3ULK2 | |
| SCHEMBL18918680 | 0.78 | ULK1 (0.52) | ULK1BTKCCNT1CDK9RET | |
| SCHEMBL18918801 | 0.77 | ULK1 (0.53) | ULK1RETFLT3ULK2AURKB | |
| SCHEMBL18918762 | 0.76 | ULK1 (0.65) | ULK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386980-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2021-10-13 | — | — | EP | disclosed |