Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23912309 | 1.00 | HRH3 (0.60) | HRH3KCNH2PIK3CDADRA1ATDP1 | |
| SCHEMBL23912306 | 0.90 | PIK3CD (0.56) | HRH3KCNH2PIK3CDMEN1ALDH1A1 | |
| SCHEMBL17458351 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458104 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458105 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458349 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458329 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458327 | 0.84 | PIK3CD (0.66) | HRH3KCNH2PIK3CDADRA1A | |
| SCHEMBL17458343 | 0.82 | PIK3CD (0.65) | HRH3KCNH2PIK3CDMEN1KMT2A | |
| SCHEMBL17458196 | 0.82 | PIK3CD (0.65) | HRH3KCNH2PIK3CDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |