Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336723 | 0.79 | MEN1 (0.39) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL531745 | 0.79 | MEN1 (0.41) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL531473 | 0.79 | MEN1 (0.41) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL532600 | 0.78 | MEN1 (0.40) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL3333078 | 0.77 | MEN1 (0.39) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL2392253 | 0.74 | KMT2A (0.39) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL531534 | 0.74 | MEN1 (0.37) | KMT2AMEN1POLBLMNAALDH1A1 | |
| SCHEMBL12262714 | 0.74 | ATM (0.50) | ATM | |
| SCHEMBL532201 | 0.73 | CYP1A2 (0.38) | KMT2AMEN1ATM | |
| SCHEMBL532611 | 0.73 | NPSR1 (0.37) | KMT2AMEN1LMNAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013008-B2 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-09-06 | — | — | US | disclosed |