Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531473 | 1.00 | MEN1 (0.41) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL2391342 | 0.79 | KMT2A (0.41) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL532600 | 0.78 | MEN1 (0.40) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL3336723 | 0.77 | MEN1 (0.39) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL3333078 | 0.77 | MEN1 (0.39) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL531534 | 0.74 | MEN1 (0.37) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL531663 | 0.74 | MEN1 (0.51) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL532201 | 0.73 | CYP1A2 (0.38) | MEN1KMT2AATM | |
| SCHEMBL532611 | 0.73 | NPSR1 (0.37) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL532131 | 0.73 | MEN1 (0.36) | MEN1KMT2AALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |