Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.47 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392187 | 0.92 | HDAC11 (0.50) | HDAC11CA12CA4CA6CA5A | |
| SCHEMBL2391857 | 0.91 | PTPN11 (0.48) | HDAC11PTPN11NR0B2RARBCA12 | |
| SCHEMBL2390064 | 0.91 | HDAC11 (0.48) | HDAC11PTPN11NR0B2RARBCA12 | |
| SCHEMBL6022849 | 0.90 | PTPN11 (0.58) | HDAC11PTPN11NR0B2RARBKDM4E | |
| SCHEMBL6022855 | 0.90 | PTPN11 (0.58) | HDAC11PTPN11NR0B2RARBKDM4E | |
| SCHEMBL2390721 | 0.90 | HDAC11 (0.49) | HDAC11PTPN11NR0B2KDM4ELMNA | |
| SCHEMBL2392575 | 0.90 | PTPN11 (0.55) | HDAC11PTPN11NR0B2KDM4ELMNA | |
| SCHEMBL2391025 | 0.88 | HDAC11 (0.50) | HDAC11RARBCA12CA4CA6 | |
| SCHEMBL1914161 | 0.87 | HDAC11 (0.49) | HDAC11RARBCA12CA4CA6 | |
| SCHEMBL2390165 | 0.86 | PTPN11 (0.59) | HDAC11PTPN11NR0B2RARBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |