Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 4/20 | 0.48 |
| ▸ | NR0B2 | Q15466 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2392187 | 0.91 | HDAC11 (0.50) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL2391357 | 0.91 | HDAC11 (0.47) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL2390064 | 0.90 | HDAC11 (0.48) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL6022883 | 0.90 | PTPN11 (0.59) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL6022887 | 0.90 | PTPN11 (0.59) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL2390721 | 0.89 | HDAC11 (0.49) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL2392575 | 0.89 | PTPN11 (0.55) | PTPN11NR0B2HDAC11LMNAKDM4E | |
| SCHEMBL2391025 | 0.88 | HDAC11 (0.50) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL1914161 | 0.86 | HDAC11 (0.49) | HDAC11LMNAKDM4EHDAC2ALDH1A1 | |
| SCHEMBL2389089 | 0.85 | HDAC11 (0.47) | PTPN11NR0B2HDAC11LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |