Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391437 | 1.00 | L3MBTL1 (0.51) | L3MBTL1HTTHPGDRXRARXRB | |
| SCHEMBL2396595 | 0.89 | TDP1 (0.49) | L3MBTL1HTTRXRARXRBRAB9A | |
| SCHEMBL2396592 | 0.89 | TDP1 (0.49) | L3MBTL1HTTRXRARXRBRAB9A | |
| SCHEMBL2396179 | 0.83 | FFAR1 (0.48) | L3MBTL1HTTRAB9ANPC1MEN1 | |
| SCHEMBL2396180 | 0.83 | FFAR1 (0.48) | L3MBTL1HTTRAB9ANPC1MEN1 | |
| SCHEMBL5462371 | 0.81 | NPC1 (0.48) | L3MBTL1HTTRAB9ANPC1MEN1 | |
| SCHEMBL5462367 | 0.81 | NPC1 (0.48) | L3MBTL1HTTRAB9ANPC1MEN1 | |
| SCHEMBL2395055 | 0.81 | NPC1 (0.46) | L3MBTL1RXRARXRBRAB9ANPC1 | |
| SCHEMBL2395052 | 0.81 | NPC1 (0.46) | L3MBTL1RXRARXRBRAB9ANPC1 | |
| SCHEMBL2395009 | 0.79 | L3MBTL1 (0.56) | L3MBTL1HTTHPGDRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |