Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 18/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 15/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 13/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914614 | 0.94 | HRH1 (0.36) | HRH1ADRA1AKCNH2ADRA1BS1PR2 | |
| SCHEMBL23913182 | 0.93 | S1PR2 (0.41) | HRH1ADRA1AKCNH2ADRA1BS1PR2 | |
| SCHEMBL23908919 | 0.86 | S1PR2 (0.35) | HRH1ADRA1AKCNH2ADRA1BS1PR2 | |
| SCHEMBL23914723 | 0.86 | PGR (0.33) | S1PR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL23908980 | 0.85 | S1PR2 (0.34) | S1PR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL23914722 | 0.83 | S1PR2 (0.36) | HRH1ADRA1AADRA1BS1PR2HRH3 | |
| SCHEMBL23915620 | 0.83 | S1PR2 (0.41) | S1PR2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL23966578 | 0.80 | S1PR2 (0.44) | HRH1ADRA1AKCNH2ADRA1BS1PR2 | |
| SCHEMBL23914726 | 0.79 | S1PR2 (0.35) | KCNH2S1PR2 | |
| SCHEMBL23909084 | 0.79 | S1PR2 (0.35) | S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GILEAD SCIENCES, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | S1PR1, S1PR3, S1PR2 | HRH1 385/4885ADRA1A 37/4885KCNH2 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.