Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 19/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 15/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 13/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914736 | 0.91 | MAPT (0.52) | HRH1ADRA1AADRA1BHRH3KCNH2 | |
| SCHEMBL23913179 | 0.85 | HRH1 (0.47) | HRH1ADRA1AADRA1BHRH3RECQL | |
| SCHEMBL23915515 | 0.84 | NPC1 (0.49) | HRH1ADRA1AADRA1BHRH3RECQL | |
| SCHEMBL27752421 | 0.83 | HRH1 (0.69) | HRH1ADRA1AADRA1BHRH3KCNH2 | |
| SCHEMBL2433319 | 0.83 | HRH1 (0.69) | HRH1ADRA1AADRA1BHRH3KCNH2 | |
| SCHEMBL2426526 | 0.83 | HRH1 (0.69) | HRH1ADRA1AADRA1BHRH3KCNH2 | |
| SCHEMBL23915513 | 0.83 | NPC1 (0.46) | HRH1ADRA1AADRA1BHRH3RECQL | |
| SCHEMBL23915623 | 0.82 | RECQL (0.47) | HRH1ADRA1AADRA1BRECQL | |
| SCHEMBL23915614 | 0.79 | GPR39 (0.62) | HRH1ADRA1AADRA1BHRH3KCNH2 | |
| SCHEMBL23914889 | 0.79 | RECQL (0.56) | HRH1ADRA1AADRA1BHRH3RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GILEAD SCIENCES, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210315893-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | S1PR1, S1PR3, S1PR2 | HRH1 385/4885ADRA1A 37/4885ADRA1B 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.