Sugi Predict

Sugi Predict / Compounds / SCHEMBL23915845

SCHEMBL23915845

SCHEMBL23915845

Cc1cccc(-c2cnc3ccc(N4CCC[C@@H]4c4cccc(F)c4)nn23)n1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NTRK1 P04629 20/20 0.77
▸ NTRK2 Q16620 14/20 0.77
▸ NTRK3 Q16288 8/20 0.77
▸ JAK2 O60674 3/20 0.77
▸ INSR P06213 3/20 0.77
▸ LYN P07948 3/20 0.77
▸ RET P07949 3/20 0.77
▸ MET P08581 3/20 0.77
▸ ROS1 P08922 3/20 0.77
▸ FGR P09769 3/20 0.77
▸ KIT P10721 3/20 0.77
▸ FGFR4 P22455 3/20 0.77
▸ FGFR3 P22607 3/20 0.77
▸ TIE1 P35590 3/20 0.77
▸ KDR P35968 3/20 0.77
▸ FLT3 P36888 3/20 0.77
▸ ALK Q9UM73 3/20 0.77
▸ ABL1 P00519 2/20 0.62
▸ LCK P06239 2/20 0.62
▸ CSF1R P07333 2/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25649807 1.00 NTRK1 (0.77) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL25649811 1.00 NTRK1 (0.77) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL1431240 0.93 NTRK1 (0.82) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL1431326 0.91 NTRK1 (0.80) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL1431234 0.91 NTRK1 (0.80) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL1431513 0.91 NTRK1 (0.80) NTRK1NTRK2NTRK3JAK2INSR
Hydrochloric Acid SCHEMBL30170800 0.90 NTRK1 (0.78) NTRK1NTRK2NTRK3JAK2INSR
Hydrochloric Acid SCHEMBL23908402 0.90 NTRK1 (0.78) NTRK1NTRK2NTRK3JAK2INSR
Hydrochloric Acid SCHEMBL23908404 0.90 NTRK1 (0.78) NTRK1NTRK2NTRK3JAK2INSR
SCHEMBL1430032 0.90 NTRK1 (0.78) NTRK1NTRK2NTRK3JAK2INSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 — — US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 — — US disclosed
WO-2023104155-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF 标新生物医药科技(上海)有限公司 2023-06-15 — — WO disclosed
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-11-25 — — US disclosed
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-10-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 NTRK1 3/4885NTRK2 21/4885NTRK3 7/4885
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, NTRK1, ERBB2 NTRK1 2/4885NTRK2 10/4885NTRK3 7/4885
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 NTRK1 3/4885NTRK2 21/4885NTRK3 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.