Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 15/20 | 0.85 |
| ▸ | CRBN | Q96SW2 | 15/20 | 0.85 |
| ▸ | STAT3 | P40763 | 4/20 | 0.66 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20208257 | 1.00 | DDB1 (0.85) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL23915252 | 1.00 | DDB1 (0.85) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL23915699 | 1.00 | DDB1 (0.85) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL20208207 | 0.99 | DDB1 (0.87) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| Trifluoroacetic Acid SCHEMBL30060912 | 0.96 | DDB1 (0.79) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL21070705 | 0.94 | CRBN (0.79) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL21069429 | 0.93 | DDB1 (0.77) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL22276517 | 0.93 | CRBN (0.84) | DDB1CRBNSTAT3GSPT1MAP2K2 | |
| SCHEMBL20153910 | 0.92 | CRBN (1.00) | DDB1CRBNSTAT3GSPT1 | |
| SCHEMBL23057485 | 0.91 | CRBN (0.90) | DDB1CRBNSTAT3GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257380-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20230257380-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2021-11-25 | — | — | US | disclosed |
| US-20210315999-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI), INC. (CN) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257380-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, ERBB2, NTRK1 | DDB1 480/4885CRBN 330/4885STAT3 3381/4885 |
| US-20210363146-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, NTRK1, ERBB2 | DDB1 418/4885CRBN 194/4885STAT3 4012/4885 |
| US-20210315999-A1 | TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE | MUSK, ERBB2, NTRK1 | DDB1 480/4885CRBN 330/4885STAT3 3381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.