Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 18/20 | 0.55 |
| ▸ | GSK3B | P49841 | 16/20 | 0.55 |
| ▸ | WNT1 | P04628 | 12/20 | 0.55 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | CLK3 | P49761 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19540426 | 0.90 | DYRK1A (0.69) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916917 | 0.83 | GSK3B (0.63) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916209 | 0.83 | DYRK1A (0.53) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916677 | 0.82 | DYRK1A (0.56) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546744 | 0.82 | WNT1 (0.81) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL19546925 | 0.81 | DYRK1A (0.65) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916284 | 0.80 | GSK3B (0.81) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916811 | 0.80 | DYRK1A (0.68) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916682 | 0.80 | DYRK1A (0.53) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916355 | 0.80 | GSK3B (0.63) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |