Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.56 |
| ▸ | WNT1 | P04628 | 9/20 | 0.56 |
| ▸ | CLK2 | P49760 | 3/20 | 0.56 |
| ▸ | CLK3 | P49761 | 3/20 | 0.56 |
| ▸ | GSK3B | P49841 | 8/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 3/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048771 | 0.85 | DYRK1A (0.51) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916678 | 0.79 | DYRK1A (0.59) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23048884 | 0.76 | DYRK1A (0.58) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916168 | 0.76 | DYRK1A (0.56) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540261 | 0.75 | DYRK1A (0.85) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540157 | 0.74 | DYRK1A (0.82) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19546878 | 0.74 | DYRK1A (0.59) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540167 | 0.73 | DYRK1A (0.65) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540237 | 0.72 | DYRK1A (0.75) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916618 | 0.72 | DYRK1A (0.53) | DYRK1AWNT1CLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |