Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 15/20 | 0.59 |
| ▸ | WNT1 | P04628 | 10/20 | 0.59 |
| ▸ | CLK2 | P49760 | 3/20 | 0.59 |
| ▸ | CLK3 | P49761 | 3/20 | 0.59 |
| ▸ | GSK3B | P49841 | 9/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23916168 | 0.79 | DYRK1A (0.56) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916602 | 0.79 | DYRK1A (0.56) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23048884 | 0.77 | DYRK1A (0.58) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540413 | 0.77 | DYRK1A (0.68) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540167 | 0.76 | DYRK1A (0.65) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540233 | 0.76 | DYRK1A (0.67) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540157 | 0.75 | DYRK1A (0.82) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL19540237 | 0.75 | DYRK1A (0.75) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916618 | 0.75 | DYRK1A (0.53) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL23916202 | 0.75 | DYRK1A (0.66) | DYRK1AWNT1CLK2CLK3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |