Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 1/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 12/20 | 0.54 |
| ▸ | KDR | P35968 | 8/20 | 0.48 |
| ▸ | SRC | P12931 | 6/20 | 0.48 |
| ▸ | ABL1 | P00519 | 5/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | PRKDC | P78527 | 7/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | HCK | P08631 | 4/20 | 0.48 |
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | CASK | O14936 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655696 | 0.84 | RET (0.54) | NUDT14NUDT5RETKDRPIK3CD | |
| SCHEMBL23917247 | 0.81 | RET (0.49) | RETKDRSRCABL1PIK3CD | |
| SCHEMBL16665690 | 0.81 | PIK3CD (0.39) | NUDT14NUDT5RETKDRSRC | |
| SCHEMBL16655326 | 0.80 | PIK3CD (0.56) | RETKDRPIK3CDLCKLYN | |
| SCHEMBL23917548 | 0.80 | RET (0.56) | RETKDRSRCABL1PIK3CD | |
| SCHEMBL16655897 | 0.80 | RET (0.54) | NUDT14NUDT5RETKDRPIK3CD | |
| SCHEMBL22692814 | 0.79 | NUDT14 (0.72) | NUDT14NUDT5KDRSRCABL1 | |
| SCHEMBL19299621 | 0.79 | RET (0.73) | RETKDRSRCABL1PIK3CD | |
| SCHEMBL23917470 | 0.78 | RET (0.56) | RETKDRSRCABL1PIK3CD | |
| SCHEMBL23917204 | 0.78 | RET (0.49) | RETKDRSRCABL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | NUDT14 1479/4885NUDT5 1329/4885RET 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.