Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | RET | P07949 | 7/20 | 0.47 |
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.41 |
| ▸ | CASK | O14936 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917283 | 0.96 | KDR (0.47) | KDRRETEIF2AK3PIK3CDPIK3CG | |
| SCHEMBL23917542 | 0.81 | PIK3CD (0.45) | KDRRETEIF2AK3PIK3CDPIK3CG | |
| SCHEMBL23917470 | 0.80 | RET (0.56) | KDRRETPIK3CDPIK3CGABL1 | |
| SCHEMBL16655753 | 0.79 | PIK3CD (0.50) | KDRRETPIK3CDABL1EGFR | |
| SCHEMBL23917471 | 0.78 | RET (0.73) | KDRRETEIF2AK3ABL1SRC | |
| SCHEMBL23917548 | 0.76 | RET (0.56) | KDRRETPIK3CDPIK3CGABL1 | |
| SCHEMBL12422371 | 0.76 | SRC (0.71) | KDRRETPIK3CDPIK3CGABL1 | |
| SCHEMBL16655701 | 0.76 | PIK3CD (0.49) | KDRRETPIK3CDABL1EGFR | |
| SCHEMBL16655766 | 0.75 | PIK3CD (0.50) | KDRRETPIK3CDABL1EGFR | |
| SCHEMBL23917445 | 0.75 | PIK3CD (0.57) | KDREIF2AK3PIK3CDPIK3CGABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | KDR 858/4885RET 753/4885EIF2AK3 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.