Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 9/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917564 | 0.83 | FGFR1 (0.43) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL23917271 | 0.80 | BTK (0.40) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL16065725 | 0.79 | PIK3CD (0.53) | EGFRPIK3CDABL1HCKSRC | |
| SCHEMBL16665750 | 0.76 | FGFR1 (0.39) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL152637 | 0.73 | PIK3CD (0.49) | FGFR1FGFR4FGFR2FGFR3EGFR | |
| SCHEMBL20093476 | 0.73 | VRK1 (0.41) | EGFRPIK3CDABL1HCKSRC | |
| SCHEMBL16665792 | 0.73 | SRC (0.45) | EGFRPIK3CDSRCPIK3CAPIK3CB | |
| SCHEMBL10855 | 0.72 | MAP4K4 (0.49) | MAP4K4PIK3CDPIK3CAPIK3CBMTOR | |
| SCHEMBL23917237 | 0.71 | MAP2K4 (0.57) | FGFR1FGFR3EGFRPIK3CDABL1 | |
| SCHEMBL16665713 | 0.71 | PIK3CD (0.36) | EGFRPIK3CDABL1HCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | FGFR1 2569/4885FGFR4 3243/4885MAP4K4 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.