Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 17/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 17/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 17/20 | 1.00 |
| ▸ | PRKDC | P78527 | 17/20 | 1.00 |
| ▸ | ABL1 | P00519 | 15/20 | 1.00 |
| ▸ | EGFR | P00533 | 15/20 | 1.00 |
| ▸ | HCK | P08631 | 15/20 | 1.00 |
| ▸ | SRC | P12931 | 15/20 | 1.00 |
| ▸ | MTOR | P42345 | 15/20 | 1.00 |
| ▸ | EPHB4 | P54760 | 15/20 | 1.00 |
| ▸ | KDR | P35968 | 14/20 | 1.00 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.76 |
| ▸ | BACE1 | P56817 | 1/20 | 0.73 |
| ▸ | BTK | Q06187 | 2/20 | 0.62 |
| ▸ | ATR | Q13535 | 2/20 | 0.62 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130637 | 0.88 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917212 | 0.87 | PIK3CD (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917200 | 0.86 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130466 | 0.85 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130500 | 0.85 | PIK3CA (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL29387520 | 0.84 | ABL1 (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL4275166 | 0.83 | PIK3CD (0.71) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917270 | 0.83 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130418 | 0.82 | PIK3CD (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917422 | 0.82 | PIK3CD (0.71) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CA 6/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.