SCHEMBL29387520

SCHEMBL29387520

CC(C)n1nc(-c2ccc(Br)c(O)c2)c2c(N)ncnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 20/20 1.00
▸ SRC P12931 20/20 1.00
▸ PIK3CD O00329 19/20 1.00
▸ PIK3CA P42336 19/20 1.00
▸ PIK3CB P42338 19/20 1.00
▸ PIK3CG P48736 19/20 1.00
▸ PRKDC P78527 19/20 1.00
▸ EGFR P00533 18/20 1.00
▸ HCK P08631 18/20 1.00
▸ KDR P35968 18/20 1.00
▸ MTOR P42345 18/20 1.00
▸ EPHB4 P54760 18/20 1.00
▸ PI4KB Q9UBF8 14/20 1.00
▸ BACE1 P56817 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3609552 0.88 SRC (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL3607753 0.86 PIK3CD (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL28897482 0.86 SRC (0.82) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL23917421 0.84 PIK3CD (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL3603461 0.84 PIK3CD (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL3614419 0.83 ABL1 (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL2434152 0.83 SRC (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL2468132 0.81 SRC (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL409057 0.81 SRC (1.00) ABL1SRCPIK3CDPIK3CAPIK3CB
SCHEMBL3612706 0.81 ABL1 (0.84) ABL1SRCPIK3CDPIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3728679-B1 COLD ROLLED AND HEAT TREATED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ARCELORMITTAL (LU) 2023-12-27 — — EP disclosed
US-20230340630-A1 COLD ROLLED AND COATED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ARCELORMITTAL (LU) 2023-10-26 — — US disclosed
EP-4217517-A1 COLD ROLLED AND COATED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ArcelorMittal (LU) 2023-08-02 — — EP disclosed
EP-4165222-A1 COLD ROLLED AND HEAT-TREATED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ArcelorMittal (LU) 2023-04-19 — — EP disclosed
US-20220340992-A1 HEAT TREATED COLD ROLLED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ARCELORMITTAL (LU) 2022-10-27 — — US disclosed
EP-4073281-A1 HEAT TREATED COLD ROLLED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ArcelorMittal (LU) 2022-10-19 — — EP disclosed
WO-2022064248-A1 COLD ROLLED AND COATED STEEL SHEET AND A METHOD OF MANUFACTURING THEREOF ARCELORMITTAL (LU) 2022-03-31 — — WO disclosed
US-11266654-B2 Apilimod compositions and methods for using same AI Therapeutics, Inc. (US) 2022-03-08 — — US disclosed
EP-3954375-A1 APILIMOD FOR USE IN THE TREATMENT OF COLORECTAL CANCER AI Therapeutics, Inc. (US) 2022-02-16 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11266654-B2 Apilimod compositions and methods for using same API5, HAAO, PDE3B ABL1 1804/4885SRC 733/4885PIK3CD 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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