Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999028 | 0.83 | HPGD (0.33) | HPGDLMNAGAA | |
| SCHEMBL3007250 | 0.81 | LMNA (0.33) | HPGDLMNAGAA | |
| SCHEMBL19022027 | 0.80 | LMNA (0.36) | HPGDLMNAGAA | |
| SCHEMBL3009276 | 0.78 | VHL (0.42) | HPGDLMNAGAA | |
| SCHEMBL25408168 | 0.78 | GRIN3B (0.36) | — | |
| SCHEMBL25408170 | 0.78 | GRIN3B (0.36) | — | |
| SCHEMBL27056225 | 0.77 | HRH3 (0.42) | HPGDLMNAGAA | |
| SCHEMBL3012488 | 0.77 | LMNA (0.51) | HPGDLMNAGAA | |
| SCHEMBL13282893 | 0.77 | HDAC3 (0.37) | LMNAGAA | |
| SCHEMBL7676173 | 0.76 | KMT2A (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11147885-B2 | ASH1L inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2021-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147885-B2 | ASH1L inhibitors and methods of treatment therewith | ASH1L, DOT1L, ASH2L | HPGD 3878/4885LMNA 2874/4885GAA 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.