Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.45 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 2/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193352 | 1.00 | MDM2 (0.48) | MDM2KMT2APAX8TDP1ATM | |
| SCHEMBL30193482 | 1.00 | MDM2 (0.48) | MDM2KMT2APAX8TDP1ATM | |
| SCHEMBL16870092 | 1.00 | MDM2 (0.48) | MDM2KMT2APAX8TDP1ATM | |
| SCHEMBL18421240 | 0.95 | MDM2 (0.52) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL30193389 | 0.95 | MDM2 (0.52) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL16870156 | 0.95 | MDM2 (0.52) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL30193403 | 0.95 | MDM2 (0.52) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL16870002 | 0.95 | MDM2 (0.52) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL29431191 | 0.92 | MDM2 (0.51) | MDM2KMT2APAX8TDP1TLR2 | |
| SCHEMBL1755616 | 0.90 | PAX8 (0.55) | MDM2KMT2APAX8TDP1TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087091-B1 | VAR2CSA-DRUG CONJUGATES | ZYMEWORKS INC (CA) | 2021-10-20 | — | — | EP | disclosed |