Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28833165 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL23923170 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL23421705 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL28833157 | 0.74 | KDM4E (0.42) | KDM4EALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL8642946 | 0.68 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL21840743 | 0.67 | ALDH1A1 (0.53) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL3740648 | 0.66 | CYP4F2 (0.58) | CYP4F2CYP4A11TNFPTPN1 | |
| SCHEMBL23014869 | 0.65 | ALDH1A1 (0.57) | KDM4EALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL21821429 | 0.65 | CYP4F2 (0.47) | KDM4EALDH1A1HSD17B10GAAKMT2A | |
| SCHEMBL4033051 | 0.65 | CYP4F2 (0.53) | KDM4EALDH1A1HSD17B10GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12071434-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2024-08-27 | — | — | US | disclosed |
| EP-3895707-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2023-10-04 | — | — | EP | disclosed |
| US-20230042358-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-02-09 | — | — | US | disclosed |
| EP-3895707-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2021-10-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230042358-A1 | HETEROCYCLIC COMPOUND | HCRTR2, HCRTR1, NTSR2 | KDM4E 1355/4885ALDH1A1 1746/4885HSD17B10 1386/4885 |
| US-12071434-B2 | Heterocyclic compound | HCRTR2, HCRTR1, NTSR2 | KDM4E 1355/4885ALDH1A1 1746/4885HSD17B10 1386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.