Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 4/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.42 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11956666 | 0.93 | MAPK1 (0.47) | MAPK1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2396649 | 0.89 | SMN1; SMN2 (0.47) | MAPK1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2394731 | 0.86 | KDM4E (0.48) | MAPK1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL11956667 | 0.86 | P4HTM (0.53) | KDM4ESMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL2394694 | 0.84 | MAPKAPK2 (0.44) | MAPK1SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL2397298 | 0.83 | MEN1 (0.46) | MAPK1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2394759 | 0.81 | MAPK1 (0.49) | MAPK1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2394353 | 0.81 | NPC1 (0.50) | MAPK1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL2394634 | 0.80 | MAPK1 (0.48) | MAPK1KDM4EL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL2396642 | 0.77 | P4HTM (0.53) | SMN1; SMN2RAB9ANPC1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189443-B1 | TRICYCLIC AMIDE COMPOUND | RES FOUND ITSUU LAB (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-8232300-B2 | Tricyclic amide compound | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213157-A1 | TRICYCLIC AMIDE COMPOUND | RXRA, RXRB, RXRG | MAPK1 3796/4885KDM4E 3386/4885L3MBTL1 4033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.