Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 7/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 4/20 | 0.39 |
| ▸ | SKP1 | P63208 | 4/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 4/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20163084 | 0.94 | HDAC3 (0.46) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163021 | 0.83 | CKS1B (0.45) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163099 | 0.79 | CKS1B (0.43) | HDAC3HDAC2CKS1BSKP1SKP2 | |
| SCHEMBL20163111 | 0.79 | ABCB1 (0.43) | HDAC3HDAC2CKS1BSKP1SKP2 | |
| SCHEMBL20163149 | 0.79 | GBA1 (0.46) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163136 | 0.79 | GPR119 (0.45) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163104 | 0.79 | GPR119 (0.44) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163038 | 0.76 | GPR119 (0.46) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163026 | 0.75 | GBA1 (0.45) | HDAC3HDAC1HDAC2GBA1CKS1B | |
| SCHEMBL20163063 | 0.74 | HDAC3 (0.59) | HDAC3HDAC1HDAC2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS LLC (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC3 7/4885HDAC1 1/4885HDAC2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.