⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28489774 | 0.83 | — | — | |
| SCHEMBL6538583 | 0.77 | DNM1 (0.32) | — | |
| SCHEMBL4370711 | 0.75 | — | — | |
| SCHEMBL1748646 | 0.69 | — | — | |
| SCHEMBL30175026 | 0.69 | — | — | |
| SCHEMBL8772922 | 0.65 | — | — | |
| SCHEMBL28813594 | 0.64 | — | — | |
| SCHEMBL19439536 | 0.63 | — | — | |
| SCHEMBL11103003 | 0.62 | — | — | |
| SCHEMBL23701241 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115427410-B | Amide or sulfonamide derivatives and application thereof | 苏州恩华生物医药科技有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-116425678-A | Hydrochloride of aminocyclobutane derivative and crystal form and preparation thereof | 苏州恩华生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-116425677-A | Salts of aminocyclobutane derivatives, crystalline forms thereof, and preparation methods and applications thereof | 苏州恩华生物医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114269747-B | 1',2' -dihydro-3'H-spiro [ cyclobutane 1,4' -isoquinoline ] -3' -one derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115650902-A | Salt of 1',2' -dihydro-3 ' H-spiro [ cyclobutane 1,4' -isoquinoline ] -3' -one derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-115427410-A | Amide or sulfonamide derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2022-12-02 | — | — | CN | disclosed |
| CN-114269747-A | 1 ', 2 ' -dihydro-3 ' H-spiro [ cyclobutane 1,4 ' -isoquinoline ] -3 ' -ketone derivative and application thereof | 苏州恩华生物医药科技有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021213353-A1 | AMIDE OR SULFONAMIDE DERIVATIVE AND USE THEREOF | 苏州恩华生物医药科技有限公司 (CN) | 2021-10-28 | — | — | WO | disclosed |