Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393641 | 0.86 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2LMNAGABRR1 | |
| SCHEMBL23930844 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2LMNAGABRR1 | |
| SCHEMBL25244034 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2LMNAGABRR1 | |
| Bromide SCHEMBL9551281 | 0.79 | HRH2 (0.49) | KDM4EALDH1A1SMN1; SMN2LMNAGABRR1 | |
| SCHEMBL23930811 | 0.78 | GABRR1 (0.43) | KDM4EALDH1A1SMN1; SMN2LMNAGABRR1 | |
| SCHEMBL3033479 | 0.77 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL1081091 | 0.74 | LMNA (0.54) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL4605287 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL20534029 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL9708864 | 0.73 | GDA (0.60) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139299-A1 | KRAS G12D PROTEIN INHIBITORS | Taiho Pharmaceutical Co., Ltd. (JP) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021215544-A1 | KRAS G12D PROTEIN INHIBITORS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |