Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Disopyramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 2/20 | 1.00 |
| ▸ | SLC22A2 | O15244 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (S)-Disopyramide SCHEMBL41811 | 1.00 | KCNH2 (1.00) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL16153 | 1.00 | KCNH2 (1.00) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL546251 | 0.99 | KCNH2 (0.98) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL9097836 | 0.96 | KCNH2 (0.93) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL41810 | 0.95 | KCNH2 (0.91) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL5167606 | 0.95 | KCNH2 (0.91) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL8511308 | 0.94 | KCNH2 (0.89) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| SCHEMBL10945741 | 0.93 | KCNH2 (0.87) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| Disopyramide SCHEMBL20770785 | 0.92 | KCNH2 (0.85) | KCNH2BLMOPRK1SLC22A2SLC22A1 | |
| SCHEMBL10798660 | 0.92 | KCNH2 (0.85) | KCNH2BLMOPRK1SLC22A2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215852-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY AND TREATMENT METHOD USING SAME COMPOSITION | (주)셀트리온 (KR) | 2021-10-28 | — | — | WO | disclosed |