(S)-Disopyramide

(S)-Disopyramide

SCHEMBL41811

CC(C)N(CC[C@](C(N)=O)(c1ccccc1)c1ccccn1)C(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of (S)-Disopyramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 3/20 1.00
BLM P54132 2/20 1.00
OPRK1 P41145 2/20 1.00
SLC22A2 O15244 1/20 1.00
SLC22A1 O15245 1/20 1.00
PGR P06401 1/20 1.00
THRB P10828 1/20 1.00
ADRB3 P13945 1/20 1.00
PMP22 Q01453 1/20 1.00
PDE3A Q14432 1/20 1.00
SLC47A1 Q96FL8 1/20 1.00
CYP3A4 P08684 1/20 1.00
ALOX15 P16050 1/20 1.00
TSHR P16473 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
CHRM3 P20309 4/20 0.45
CHRM2 P08172 3/20 0.45
CHRM1 P11229 2/20 0.45
CYP2D6 P10635 2/20 0.45
LMNA P02545 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Disopyramide SCHEMBL23931452 1.00 KCNH2 (1.00) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL16153 1.00 KCNH2 (1.00) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL546251 0.99 KCNH2 (0.98) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL9097836 0.96 KCNH2 (0.93) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL41810 0.95 KCNH2 (0.91) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL5167606 0.95 KCNH2 (0.91) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL8511308 0.94 KCNH2 (0.89) KCNH2BLMOPRK1SLC22A2SLC22A1
SCHEMBL10945741 0.93 KCNH2 (0.87) KCNH2BLMOPRK1SLC22A2SLC22A1
Disopyramide SCHEMBL20770785 0.92 KCNH2 (0.85) KCNH2BLMOPRK1SLC22A2SLC22A1
SCHEMBL10798660 0.92 KCNH2 (0.85) KCNH2BLMOPRK1SLC22A2SLC22A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3094 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025038939-A9 POROUS PELLETS AND PROCESS OF MANUFACTURING THE SAME SPI PHARMA, INC. (US) 2025-04-17 WO claimed
WO-2025038939-A1 POROUS PELLETS AND PROCESS OF MANUFACTURING THE SAME SPI PHARMA, INC. (US) 2025-02-20 WO claimed
US-20240282425-A1 AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS LOW GORDON KEITH (US) 2024-08-22 US claimed
EP-4066850-A2 PEPTIDES AND METHODS OF TREATING DYSTROPHY-RELATED DISORDERS USING THE SAME Bioincept LLC (US) 2022-10-05 EP claimed
EP-3509607-A1 FORMULATION FOR PREVENTING OR TREATING DENTIN-ASSOCIATED SYMPTOMS OR DISEASES, AND METHOD USING THE SAME Sancastle Worldwide Corporation (TW) 2019-07-17 EP claimed
US-20190133924-A1 Alcohol-Resistant Formulations CIMA LABS INC (US) 2019-05-09 US claimed
CN-108064157-A Formulations for preventing or treating dentinal tubule associated symptoms or diseases and methods of use thereof 圣凯瑟世界股份有限公司 2018-05-22 CN claimed
WO-2018046978-A1 FORMULATION FOR PREVENTING OR TREATING DENTIN-ASSOCIATED SYMPTOMS OR DISEASES, AND METHOD USING THE SAME SANCASTLE WORLDWIDE CORPORATION (TW) 2018-03-15 WO claimed
US-20180064757-A1 FORMULATION FOR PREVENTING OR TREATING DENTIN-ASSOCIATED SYMPTOMS OR DISEASES, AND METHOD USING THE SAME SANCASTLE WORLDWIDE CORPORATION (TW) 2018-03-08 US claimed
US-20170304388-A1 NEW INDICATION OF CARDIOVASCULAR DRUGS FOR PREPARATION OF CANCER INHIBITION PHARMACEUTICAL COMPOSITION LAUNX BIOMEDICAL CO., LTD. (TW) 2017-10-26 US claimed
US-5166142-A Anticholesterol agents such as quinidine, procainamide or disopyramide UNIVERSITY OF ROCHESTER (US) 1992-11-24 US claimed
US-5026559-A Multilayer walled coating KINAFORM TECHNOLOGY, INC. (US) 1991-06-25 US claimed
EP-0425659-A1 SUSTAINED RELEASE PHARMACEUTICAL PREPARATIONS HAVING pH CONTROLLED MEMBRANE COATINGS. KINAFORM TECHNOLOGY INC (US) 1991-05-08 EP claimed
US-4983401-A Sustained release pharmaceutical preparations having pH controlled membrane coatings KINAFORM TECHNOLOGY, INC. (US) 1991-01-08 US claimed
WO-1990014077-A1 SUSTAINED RELEASE PHARMACEUTICAL PREPARATIONS HAVING pH CONTROLLED MEMBRANE COATINGS KINAFORM TECHNOLOGY, INC. (US) 1990-11-29 WO claimed
EP-0391518-A2 Sustained-release pharmaceutical preparation KINAFORM TECHNOLOGY, INC. (US) 1990-10-10 EP claimed
US-4789549-A IN A WATER SOLUBLE POLYMER MATRIX COATED WITH POLYMERIC SEMIPERMEABLE MEMBRANE WARNER-LAMBERT COMPANY (US) 1988-12-06 US claimed
EP-0282011-A2 Sustained release pharmaceutical dosage forms WARNER-LAMBERT COMPANY (US) 1988-09-14 EP claimed
EP-0239361-A1 Sustained-release pharmaceutical preparation KINAFORM TECHNOLOGY, INC. (US) 1987-09-30 EP claimed
EP-0189861-A2 Percutaneous absorption accelerator for ionic water-soluble medicine SHOWA DENKO KABUSHIKI KAISHA (JP) 1986-08-06 EP claimed