Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16870100 | 0.78 | OPRM1 (0.49) | OPRM1OPRL1OPRK1HDAC3HDAC1 | |
| SCHEMBL13813863 | 0.77 | SLC6A4 (0.53) | OPRM1OPRL1OPRK1SLC6A4SLC6A3 | |
| SCHEMBL3224276 | 0.77 | SLC6A4 (0.53) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL16867371 | 0.77 | OPRM1 (0.47) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| Hydrochloric Acid SCHEMBL28693173 | 0.76 | OPRM1 (0.46) | OPRM1OPRL1OPRK1BACE1HCAR3 | |
| Hydrochloric Acid SCHEMBL28693211 | 0.76 | SLC6A4 (0.51) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL5643705 | 0.75 | OPRM1 (0.48) | OPRM1OPRL1OPRK1OGFRL1 | |
| SCHEMBL1822928 | 0.74 | OPRM1 (0.74) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL16869995 | 0.74 | OPRM1 (0.45) | OPRM1OPRL1OPRK1BACE1TACR1 | |
| SCHEMBL16867369 | 0.74 | OPRM1 (0.47) | OPRM1OPRL1OPRK1BACE1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3087091-B1 | VAR2CSA-DRUG CONJUGATES | ZYMEWORKS INC (CA) | 2021-10-20 | — | — | EP | disclosed |