Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.83 |
| ▸ | SRC | P12931 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | GAK | O14976 | 4/20 | 0.60 |
| ▸ | BRAF | P15056 | 3/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.60 |
| ▸ | STK10 | O94804 | 3/20 | 0.60 |
| ▸ | PIP4K2C | Q8TBX8 | 3/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.60 |
| ▸ | BUB1 | O43683 | 2/20 | 0.60 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.60 |
| ▸ | CIT | O14578 | 2/20 | 0.60 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.60 |
| ▸ | STK17B | O94768 | 2/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578659 | 0.93 | EGFR (0.92) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL28696278 | 0.93 | EGFR (0.92) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL828788 | 0.91 | EGFR (1.00) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL29483201 | 0.91 | EGFR (1.00) | EGFRSRCKDRGAKBRAF | |
| Hydrochloric Acid SCHEMBL20534441 | 0.90 | EGFR (0.98) | EGFRSRCKDRGAKBRAF | |
| Hydrochloric Acid SCHEMBL30133464 | 0.90 | EGFR (0.98) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL28700304 | 0.89 | EGFR (0.84) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL29579338 | 0.89 | EGFR (0.84) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL826406 | 0.89 | EGFR (0.78) | EGFRSRCKDRGAKBRAF | |
| SCHEMBL18651673 | 0.88 | EGFR (0.77) | EGFRSRCKDRGAKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609875-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF N-(3-ETHYNYLPHENYL)-7-METHOXY-6-(3-MORPHOLINOPROPOXY) QUINAZOLIN -4-AMINE DIHYDROCHLORIDE | NATCO PHARMA LTD (IN) | 2021-10-20 | — | — | EP | disclosed |