Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.92 |
| ▸ | SRC | P12931 | 6/20 | 0.71 |
| ▸ | KDR | P35968 | 4/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.66 |
| ▸ | BRAF | P15056 | 3/20 | 0.66 |
| ▸ | GAK | O14976 | 3/20 | 0.66 |
| ▸ | CIT | O14578 | 2/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.66 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.66 |
| ▸ | STK17B | O94768 | 2/20 | 0.66 |
| ▸ | STK10 | O94804 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578659 | 1.00 | EGFR (0.92) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL828788 | 0.96 | EGFR (1.00) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL29483201 | 0.96 | EGFR (1.00) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL29579338 | 0.95 | EGFR (0.84) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL28700304 | 0.95 | EGFR (0.84) | EGFRSRCKDRERBB2BRAF | |
| Hydrochloric Acid SCHEMBL30133464 | 0.95 | EGFR (0.98) | EGFRSRCKDRERBB2BRAF | |
| Hydrochloric Acid SCHEMBL20534441 | 0.95 | EGFR (0.98) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL23934779 | 0.93 | EGFR (0.83) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL12743351 | 0.93 | EGFR (0.80) | EGFRSRCKDRERBB2BRAF | |
| SCHEMBL826406 | 0.92 | EGFR (0.78) | EGFRSRCKDRERBB2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069913-B | Bis (morpholinylalkoxy) quinazoline derivative and application thereof in anti-tumor aspect | 陕西师范大学 | 2022-03-01 | — | — | CN | claimed |
| CN-108069913-B | Bis (morpholinylalkoxy) quinazoline derivative and application thereof in anti-tumor aspect | 陕西师范大学 | 2022-03-01 | — | — | CN | disclosed |