Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ATP4A | P20648 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATP4B | P51164 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1465482 | 0.86 | SLC2A1 (0.49) | SLC2A1CYP1A2HDAC6MEN1CYP3A4 | |
| SCHEMBL18906399 | 0.82 | ELANE (0.43) | MMP3CYP1A2HDAC6MEN1CYP3A4 | |
| SCHEMBL1465669 | 0.82 | MGAM (0.46) | SGMS2CYP1A2HDAC6MEN1CYP3A4 | |
| SCHEMBL28877560 | 0.81 | FOLH1 (0.53) | MCL1MEN1KMT2AMAOB | |
| SCHEMBL16981016 | 0.81 | TTR (0.51) | APPMCL1SLC2A1SIRT1CYP1A2 | |
| SCHEMBL1464842 | 0.81 | MAPK1 (0.55) | APPCYP1A2HDAC6MEN1CYP3A4 | |
| SCHEMBL30028270 | 0.81 | MEN1 (0.56) | APPCYP1A2MEN1CYP3A4CYP2D6 | |
| SCHEMBL6355596 | 0.81 | MEN1 (0.56) | APPCYP1A2MEN1CYP3A4CYP2D6 | |
| SCHEMBL9454596 | 0.80 | APP (0.50) | APPMCL1SLC2A1SIRT1CYP1A2 | |
| SCHEMBL6895161 | 0.80 | ALDH1A1 (0.50) | MEN1MAPK1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605275-B | Synthesis method of bromine-free dopamine hydrochloride | 上海现代哈森（商丘）药业有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-114605275-A | Novel synthesis method of dopamine without bromine hydrochloride | 上海现代哈森（商丘）药业有限公司 | 2022-06-10 | — | — | CN | disclosed |
| US-9051279-B2 | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2015-06-09 | — | — | US | disclosed |
| CN-102770182-B | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | disclosed |
| EP-2516009-B1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | NOVARTIS AG (CH) | 2014-09-24 | — | — | EP | disclosed |
| US-20130281473-A1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | NOVARTIS AG (CH) | 2013-10-24 | — | — | US | disclosed |
| US-8440693-B2 | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2013-05-14 | — | — | US | disclosed |
| CN-102770182-A | Substituted isoquinolinones and quinazolinones | NOVARTIS AG | 2012-11-07 | — | — | CN | disclosed |
| EP-2516009-A1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | Novartis AG (CH) | 2012-10-31 | — | — | EP | disclosed |
| US-20110230457-A1 | Substituted Isoquinolinones and Quinazolinones | NOVARTIS AG (CH) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230457-A1 | Substituted Isoquinolinones and Quinazolinones | MDM4, MDM2, TP53 | APP 1098/4885MCL1 395/4885MMP3 4759/4885 |
| US-20130281473-A1 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES | MDM4, MDM2, TP53 | APP 1098/4885MCL1 395/4885MMP3 4759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.