Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935067 | 0.89 | LRRK2 (0.41) | LRRK2 | |
| SCHEMBL23934987 | 0.89 | LRRK2 (0.51) | LRRK2 | |
| SCHEMBL18606460 | 0.82 | LRRK2 (0.51) | LRRK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18606440 | 0.80 | LRRK2 (0.53) | LRRK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23934993 | 0.77 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL18606605 | 0.76 | LRRK2 (0.48) | LRRK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23935144 | 0.74 | LRRK2 (0.58) | LRRK2 | |
| SCHEMBL18606457 | 0.71 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL18634607 | 0.70 | LRRK2 (0.69) | LRRK2 | |
| SCHEMBL18606596 | 0.69 | LRRK2 (0.58) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |