Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23934987 | 0.89 | LRRK2 (0.51) | LRRK2 | |
| SCHEMBL23935067 | 0.88 | LRRK2 (0.41) | LRRK2JAK2JAK1JAK3 | |
| SCHEMBL23934972 | 0.81 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL18606372 | 0.80 | LRRK2 (0.57) | LRRK2 | |
| SCHEMBL23935144 | 0.79 | LRRK2 (0.58) | LRRK2 | |
| SCHEMBL18606370 | 0.78 | LRRK2 (0.62) | LRRK2JAK2JAK3 | |
| SCHEMBL23934975 | 0.77 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL25020969 | 0.77 | LRRK2 (0.78) | LRRK2 | |
| SCHEMBL25020888 | 0.76 | LRRK2 (0.79) | LRRK2 | |
| SCHEMBL23935232 | 0.76 | LRRK2 (0.67) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |