Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935003 | 0.86 | LRRK2 (0.41) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23934989 | 0.84 | LRRK2 (0.42) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23935127 | 0.82 | LRRK2 (0.43) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL25020868 | 0.82 | LRRK2 (0.41) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23935247 | 0.80 | LRRK2 (0.42) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23935076 | 0.80 | LRRK2 (0.43) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23935014 | 0.77 | LRRK2 (0.50) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL23935012 | 0.77 | LRRK2 (0.43) | LRRK2PIK3CAPIK3CD | |
| SCHEMBL25022262 | 0.76 | LRRK2 (0.41) | LRRK2PIK3CAMTORATMPIK3CD | |
| SCHEMBL23935225 | 0.74 | LRRK2 (0.40) | LRRK2PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |