Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23922646 | 0.76 | LRRK2 (0.51) | — | |
| SCHEMBL18658907 | 0.76 | LRRK2 (0.51) | — | |
| SCHEMBL18606520 | 0.76 | LRRK2 (0.51) | — | |
| SCHEMBL23934997 | 0.74 | LRRK2 (0.45) | — | |
| SCHEMBL23934965 | 0.72 | LRRK2 (0.49) | — | |
| SCHEMBL4302608 | 0.68 | KDM4E (0.40) | PDE10AKDM4ETLR7 | |
| SCHEMBL4312799 | 0.66 | SMN1; SMN2 (0.40) | PDE10ATLR7 | |
| SCHEMBL18606425 | 0.65 | JAK1 (0.45) | — | |
| SCHEMBL27666505 | 0.65 | TLR7 (0.44) | TLR7 | |
| SCHEMBL12888448 | 0.65 | HPGD (0.42) | PDE10ATLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |