Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22797733 | 0.84 | GAA (0.54) | GAALMNAMETTP53MAPT | |
| SCHEMBL25087345 | 0.79 | SLC6A2 (0.41) | MAPTLIPGSMN1; SMN2 | |
| SCHEMBL1254474 | 0.77 | GPR84 (0.47) | MAPTIFNAR1 | |
| SCHEMBL20824761 | 0.76 | GAA (0.53) | GAALMNATP53MAPTBRD4 | |
| SCHEMBL13833580 | 0.73 | GAA (0.57) | GAALMNATP53MAPTBRD4 | |
| SCHEMBL15519326 | 0.72 | GAA (0.56) | GAALMNATP53MAPTBRD4 | |
| SCHEMBL5140683 | 0.72 | GAA (0.56) | GAALMNATP53MAPTBRD4 | |
| SCHEMBL8268239 | 0.72 | GAA (0.56) | GAALMNATP53MAPTBRD4 | |
| SCHEMBL30098515 | 0.72 | GAA (0.56) | GAATP53MAPTBRD4POLB | |
| SCHEMBL8063482 | 0.72 | GAA (0.56) | GAALMNAMETTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896064-A1 | 4,6-DIAMINO-QUINOLINE-3-CARBONITRILE DERIVATIVES AS CANCER OSAKA THYROID (COT) MODULATORS FOR TREATING CROHN'S DISEASE AND ULCERATIVE COLITIS | Gilead Sciences, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |