Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032039 | 0.81 | HSD17B10 (0.46) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL11033869 | 0.81 | CHRM5 (0.47) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL15032038 | 0.78 | MAPT (0.44) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL27517098 | 0.77 | POLB (0.58) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL21214009 | 0.77 | SMN1; SMN2 (0.66) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL17950903 | 0.77 | SMYD3 (0.60) | CHRM5CHRM3SIGMAR1SMYD3POLB | |
| SCHEMBL7344790 | 0.75 | GLA (0.55) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL905223 | 0.75 | GLA (0.55) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL18205586 | 0.75 | POLB (0.43) | CHRM5CHRM3MAPTHSD17B10MEN1 | |
| SCHEMBL1316096 | 0.74 | SIGMAR1 (0.69) | CHRM5CHRM3SIGMAR1SMYD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022006331-A2 | PYRIDINE-1,5-DIONES EXHIBITNG MNK INHIBITION AND THEIR METHOD OF USE | 4E THERAPEUTICS, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| EP-3475277-B1 | ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF | BIOIMICS AB (SE) | 2021-10-20 | — | — | EP | disclosed |