Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 8/20 | 0.50 |
| ▸ | NR0B2 | Q15466 | 3/20 | 0.50 |
| ▸ | RARB | P10826 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | PTPRCAP | Q14761 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391835 | 0.93 | PTPN11 (0.48) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2406294 | 0.88 | PTPN11 (0.64) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2406297 | 0.88 | PTPN11 (0.64) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2390735 | 0.85 | HDAC11 (0.40) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2404988 | 0.84 | PTPN11 (0.58) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2404992 | 0.84 | PTPN11 (0.58) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2389503 | 0.83 | RARB (0.52) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2391143 | 0.83 | RARB (0.52) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2391090 | 0.82 | PTPN11 (0.74) | PTPN11NR0B2RARBHDAC11HDAC2 | |
| SCHEMBL2394186 | 0.82 | RARB (0.51) | PTPN11NR0B2RARBHDAC11HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |