Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937675 | 0.83 | TUBB4A (0.39) | HPGDTSHRHTTSMN1; SMN2HDAC8 | |
| SCHEMBL17113154 | 0.82 | USP2 (0.48) | HPGDTSHRSMN1; SMN2TUBB4ATUBB | |
| SCHEMBL30317473 | 0.73 | MAPK11 (0.53) | HPGDTSHRHTTSMN1; SMN2HDAC8 | |
| SCHEMBL8569571 | 0.70 | MAOB (0.60) | HPGDTSHRHTTSMN1; SMN2HDAC6 | |
| SCHEMBL15910569 | 0.70 | PRKCI (0.41) | TSHRSMN1; SMN2KDM4EPRKCI | |
| SCHEMBL23937850 | 0.69 | BAZ2B (0.40) | HPGDTSHRTUBB4ATUBBTUBA3C | |
| SCHEMBL25014733 | 0.69 | RET (0.44) | PLAUACSS2BRD4PLK1 | |
| SCHEMBL15910789 | 0.68 | CSNK2A1 (0.45) | HPGDTSHRHTTSMN1; SMN2HDAC8 | |
| SCHEMBL940919 | 0.68 | PLAU (0.53) | HPGDTSHRHTTSMN1; SMN2HDAC8 | |
| SCHEMBL29582662 | 0.68 | PLAU (0.53) | HPGDTSHRHTTSMN1; SMN2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |