Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12670777 | 0.78 | NFATC1 (0.37) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL20656340 | 0.76 | NFATC1 (0.36) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL21893814 | 0.76 | DHFR (0.44) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL30702049 | 0.76 | NFATC1 (0.36) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL31419752 | 0.76 | NFATC1 (0.37) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL29115222 | 0.76 | NFATC1 (0.37) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL26621249 | 0.74 | ATR (0.33) | NFATC1GSK3BDYRK1AATRPIK3CB | |
| SCHEMBL14616909 | 0.73 | CCR4 (0.37) | NFATC1GSK3BDYRK1AATRHSD11B1 | |
| SCHEMBL15164815 | 0.73 | RHEB (0.39) | NFATC1GSK3BDYRK1APIK3CBMAPT | |
| SCHEMBL27035857 | 0.73 | NFATC1 (0.34) | NFATC1GSK3BDYRK1AATRPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |