Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 5/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12303981 | 0.78 | ADORA2A (0.42) | FEN1NTRK1LTKTYRO3NTRK2 | |
| SCHEMBL14737613 | 0.76 | NTRK1 (0.35) | FEN1NTRK1LTKTYRO3NTRK2 | |
| SCHEMBL10678369 | 0.75 | ESR1 (0.39) | FEN1ESR1 | |
| SCHEMBL22104565 | 0.73 | HTT (0.39) | FEN1NTRK1LTKTYRO3NTRK2 | |
| SCHEMBL10676219 | 0.73 | ESR1 (0.40) | FEN1ESR1 | |
| SCHEMBL23937789 | 0.71 | FEN1 (0.32) | FEN1ERCC5ESR1 | |
| SCHEMBL13523827 | 0.68 | MAPK1 (0.41) | — | |
| SCHEMBL844706 | 0.66 | NTRK1 (0.43) | NTRK1LTKTYRO3NTRK2CLK4 | |
| SCHEMBL20631050 | 0.65 | NTRK1 (0.36) | FEN1NTRK1LTKTYRO3NTRK2 | |
| SCHEMBL18108799 | 0.65 | SMN1; SMN2 (0.46) | ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |